Steric hindrance refers to the repulsion or interference that occurs when bulky groups attached to molecules come into close proximity with each other.

This interference can restrict the movement or reactions of the molecules, affecting their overall behaviour.

An analogy for steric hindrance could be like trying to fit a large piece of furniture through a narrow doorway.

The bulkiness of the furniture can make it difficult to manoeuvre through the door, just as bulky groups on molecules can make it challenging for them to interact or react effectively.

Steric hindrance is significant in chemistry because it can impact the shape and reactivity of molecules, affecting various chemical processes such as molecular interactions, reactions, and biological activities.